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New drug combo for superior breast most cancers permitted for NHS in England – Most cancers Analysis UK

 

A breast cancer cell.

The National Institute of Health and Care Excellence (NICE) has approved the use of a new combination of drugs for some adults with an advanced form of breast cancer that spreads to other parts of the body.

The combination of abemaciclib (Verzenios) and fulvestrant (Faslodex) was originally made available through the Cancer Drugs Fund in 2019 as more efficacy data was collected. The latest decision means the drugs are now routinely available from the NHS.

Ben Chiu, Policy Manager at CRUK, said it was “brilliant news” that people affected by this type of breast cancer will continue to have this treatment.

Scientists from Cancer Research UK laid the foundation for its development over 30 years ago.

How does it work?

Abemaciclib is a type of medicine called a cyclin-dependent kinase 4/6 inhibitor (CDK4 / 6). It blocks proteins in cancer cells that allow the cancer to divide and grow.

Human versions of cyclin-dependent kinases were discovered by Paul Nurse, a scientist with Cancer Research UK at the London Research Institute (LRI). For this discovery, Nurse was awarded the Nobel Prize in 2001 together with his colleague Tim Hunt and a US researcher named Leland Hartwell, who first identified cyclin-dependent kinases in yeast.

A life-extending alternative

According to Meindest Boysen, director of the Center for Health and Technology Assessment at NICE, people with this form of advanced breast cancer would normally be treated with exemestane plus everolimus at this stage.

However, this combination was found to be poorly tolerated by patients and was only used in a small number of patients because it had similar effects on quality of life as chemotherapy.

However, following the NICE decision, patients can now access abemaciclib as a treatment option. The drug will be available to patients whose advanced hormone receptor-positive, HER2-negative breast cancer has spread to other parts of the body after endocrine therapy.

Abemaciclib plus fulvestrant was not directly compared with exemestane plus everolimus in clinical trials. However, an indirect comparison suggests that people taking abemaciclib plus fulvestrant had longer before their disease got worse and lived longer than people taking exemestane plus everolimus.

During the consultation period, experts heard the value of this drug as a treatment option for patients as it is an alternative to other drugs and has other side effects.

Boysen said, “Advanced breast cancer is an incurable disease, and the goal of treatment is to delay the worsening and extend survival. The committee heard that CDK4 / 6 inhibitors such as abemaciclib were welcomed by patients as they can delay the time it takes for their cancer to get worse, thereby delaying or avoiding the need for chemotherapy. ”

More clinical data needed

NICE’s February draft guideline did not support routine use in England as it was not considered cost-effective. But based on an improved patient access scheme and economic modeling data provided by creators Eli Lilly, the NICE committee decided that abemaciclib could be recommended as a cost-effective use of NHS resources.

It will now move from being temporarily available through the Cancer Drugs Fund to being a routine start-up.

Chiu commented, “It shows the importance of the Cancer Drugs Fund in providing cancer patients with new treatments for their disease.”

Wales and Northern Ireland tend to follow NICE recommendations so the combination is likely to be available in these countries too. Scotland has its own approval process through the Scottish Medicines Consortium (SMC).

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